Friday, June 14, 2024

Why progesterone and pregnancy are interrelated to each other?


  • Progesterone, the hormone of pregnancy, conducts a pivotal and indisputable part in the establishment and maintenance of pregnancy in females.
  • Progesterone is a hormone that’s produced after ovulation, and there needs to be a particular level of progesterone to sustain a pregnancy. 
  • When progesterone levels are low, some think it can potentially lead to recurrent miscarriages.
  • Progesterone is also called pregnancy hormone because conception and healthy pregnancy depend on the progesterone hormone. 
  • It is a hormone produced naturally by the ovaries each month, and progesterone plays a significant role both before and during pregnancy.

In this article, you will find how to increase the progesterone level to get pregnant.

  • During pregnancy, progesterone is a hormone produced early in pregnancy by a cyst on the ovary called the Corpus Luteum. 
  • This cyst of the ovarian follicles continues to grow progesterone for teen weeks during pregnancy.
  • Whereas expression of progesterone receptor protein during pregnancy in the ovine uterus. 
  • Progesterone induces a manifest of proteins in the endometrial glandular epithelium (GE) that are secreted into the uterine lumen. 
  • And progesterone modulates the immune system so that the mother’s immune system does not reject the baby. 
  • It is an excellent hormone and is needed by the body for the pregnancy to go up to term. 
  • Progesterone is key to developing a suitable environment for the ovaries to harbor the fetus by keeping the uterus muscle relaxed and helping the immune system tolerate foreign DNA.
  • Progesterone is also helpful in those women who are unable to conceive, i.e. in case of PCOD, 
  • Thyroid problems, or Luteal Phase Defect, progesterone starts just after fertilization so that the pregnancy grows even before the individual skips periods.
  • Progesterone is also vital in suppressing the maternal immunologic response to fetal antigens, thereby averting maternal rejection of the trophoblast.
  • And, of course, progesterone produces and maintains the endometrium to allow implantation primarily. 

You can get information about how to increase the progesterone level to get pregnant.

There are many IVF clinics in Noida who will guide and assist you on this.

What role does the progesterone hormone play in pregnancy?

If ovulation occurs, progesterone hormone rises to support the pregnancy. But if the level of progesterone is low, it may affect the conception or pregnancy complications increase.

Progesterone helps implant the egg in the uterus to occur in pregnancy by preparing the uterus lining to enable implantation. 

It supports the uterine lining by providing nutrients to the developing fetus.

Progesterone hormones thicken the cervix and create the mucus plug, which helps in blocking bacteria from entering the uterus.

If the individual has conceived via IVF, then the progesterone hormone supplement is prescribed by the doctors because medications and procedures of IVF can damage the cells that produce progesterone hormones.

As mentioned above, progesterone plays an essential role in maintaining pregnancy at around seven to nine weeks of gestation, and the placenta takes over. 

It begins to produce this, and during the second half of the pregnancy, progesterone kind of helps to keep the uterus calm and quiet and helps prevent the water from breaking prematurely.

There are many ways to learn about how to increase the progesterone level to get pregnant. Many IVF clinics in noida promote this idea and medicate you accordingly.

What if the level of progesterone hormone is low during pregnancy?

If the level of progesterone hormone is low during pregnancy, the doctor may prescribe progesterone supplements to support a healthy pregnancy.

You must learn how to increase the progesterone level to get pregnant.

Many IVF clinics in Noida help you with this through their services.

Progesterone hormone supplements are available in forms such as:

 (i). Vaginal gels

    • Used once a day for progesterone supplementation.

    • Unique, the only once-daily FDA-approved progesterone for Assisted reproductive technology (ART) for up to twelve weeks of pregnancy.

 (ii). Vaginal suppositories

    • Compounded at vital suit pharmacists.

    • Usually wax-based

    • Extensively used but not FDA approved.

    • Usually consumed up to 2 to 3 times in a day.

    • Leakage can be mucky.

 (iii). Vaginal inserts

     • Designed for vaginal usage.

     • It is effective for women under 35 years. 

They are used two to three times a day.

 (iv). Injections

      • An oil-based solution (usually called progesterone in oil).

      • Injected into the buttocks once a day.

 (v). Progesterone oral capsules, used vaginally

     • Usually used up to 3 times in a day. Minimal side effects when capsules are consumed vaginally instead of orally.

Blood tests measure levels of progesterone hormone. Low progesterone levels may cause:

• Ectopic pregnancy

• Miscarriage

• Premature birth

• Vaginal dryness

• And other pregnancy complications

Progesterone cannot be given to every female. There are some indications

 (i). Threatened abortion

    If the individual has had bleeding during pregnancy.

 (ii). Bad Obstetric History

     If the individual has had more than three recurrent miscarriages

 (iii). The individual having preterm labor, i.e. the individual has gone into labor before 28 weeks.

 (iv). The individual has Cervical Incompetence, i.e. the mouth of the uterus “Cervix” opens prematurely, leading to abortions.

Progesterone elevation during pregnancy has programming effects:

 (i). Maternal progesterone supplementation in premature pregnancy would increase fetal progesterone.

 (ii). An increase in fetal progesterone would change the function of developing reproductive tissues.

 (iii). Increased progesterone would be metabolized to other bioactive steroids in the fetus. 

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